Native vs. Hydrolyzed Collagen: What’s the Difference?

By Dr. Joan van Wyngaard

Most collagen supplements are hydrolyzed, meaning they’re broken down into peptides for digestion and general protein support. While useful, hydrolyzed collagen doesn’t actively interact with the immune system or directly preserve joint cartilage.

Native (undenatured) type II collagen, on the other hand, remains intact during digestion. In small, clinically studied doses (typically just 40 mg), it triggers a process called oral tolerance - essentially retraining the immune system to stop mistakenly attacking joint cartilage. This helps reduce inflammation and preserves cartilage structure over time.

Clinically Backed Benefits

Research into native type II collagen is growing - and the results are promising. Clinical studies have shown that supplementation can:

  • Improve knee extension and joint flexibility
  • Reduce joint discomfort following physical activity
  • Support joint function even in healthy adults

In one study, participants who took 40 mg of undenatured type II collagen daily experienced a significant improvement in knee range of motion compared to placebo-particularly after strenuous activity. This makes it a valuable option not just for aging adults, but also weekend warriors, runners, gym-goers, and anyone wanting to stay limber and agile.

Why Daily Use Matters

Joint health isn’t something that can be fixed overnight. Like most long-term strategies, consistency is key. Because undenatured type II collagen works at the immunological level, its benefits build gradually. Most clinical improvements are seen after 8–12 weeks of daily use, with ongoing intake helping to maintain joint comfort over the long term.

And with a low effective dose of just 40 mg per day, it's incredibly easy to incorporate into your supplement routine-whether you stack it with vitamins, minerals, or other joint-supporting nutrients.

The Vitadurance Edge

At Vitadurance, we recognize the importance of supporting your joints not just for recovery-but for longevity, performance, and quality of life. That’s why undenatured type II collagen is one of the foundational ingredients in our Joint Active formulation. It's scientifically backed, highly effective at low doses, and tailored for anyone who wants to keep moving with freedom and ease.

Conclusion: Small Dose, Big Impact

Joint pain and stiffness don’t have to be accepted as a normal part of aging-or an inevitable side effect of an active life. With native type II collagen, you're not just managing symptoms; you're addressing the underlying mechanisms of joint health.

If you’ve ever wondered what more you could be doing to protect your joints now and into the future-this is it.

Undenatured Type II Collagen: A small daily habit for long-term mobility.

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