MG-LZ8 and Sleep: The Cortisol-Melatonin Connection

By Craig Fourie

MG-LZ8, a full-spectrum Ganoderma lucidum extract, has demonstrated significant immune-modulating, anti-inflammatory, and cortisol-regulating properties. Recent insights suggest that its effects on cortisol levels may have implications for sleep quality and melatonin production, positioning MG-LZ8 as a potential natural sleep aid. 😴

The Relationship Between Cortisol and Melatonin

Cortisol and melatonin have an inverse relationship in the body's circadian rhythm (Figure 1).

Figure 1 - The Circadian Rhythm

The 2017 Nobel Prize in Physiology or Medicine went to Jeffrey C. Hall, Michael Rosbash, and Michael W. Young for their work on circadian rhythms - the internal biological clock that governs sleep, metabolism, and energy cycles. Their research showed how genes like PER regulate our body’s natural rhythm in response to light and dark. Why does this matter? Because disruptions in circadian rhythms - from poor sleep, stress, or irregular schedules - can lead to fatigue, mood imbalances, and metabolic issues.

Adaptogens can be likened to act like biological buffers, when used correctly to assist your body to reset, recover, and promote healthy circadian rhythms - whether you're bouncing back from a long day, jet lag, battling with chronic stress or are a highly active individual.

Cortisol peaks in the morning to promote wakefulness and declines in the evening, allowing melatonin to rise and induce sleep. Chronic stress, inflammation, or dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis can result in persistently elevated cortisol levels, which suppress melatonin production and disrupt sleep patterns.

MG-LZ8’s Role in Cortisol Modulation

Studies indicate that MG-LZ8 helps regulate cortisol levels by modulating immune responses and reducing inflammation. By lowering cortisol, MG-LZ8 may help restore the natural circadian rhythm, allowing for optimal melatonin synthesis and improved sleep quality.

  • Pre-clinical evidence: MG-LZ8 has been shown to support immune homeostasis and balance stress-related cortisol fluctuations.
  • Potential human application: By promoting a reduction in nighttime cortisol levels, MG-LZ8 may aid in the natural production of melatonin, thereby enhancing sleep onset and duration.

Additionally, 15 mg of MG-LZ8 antler extract is equivalent to approximately 5,200 mg of conk mushroom powder, highlighting its potency compared to standard Ganoderma lucidum formulations. This higher bioavailability suggests that MG-LZ8 may exert stronger physiological effects at lower doses.

Comparison to Clinical Trials on Ganoderma lucidum for Sleep

Clinical trials investigating Ganoderma lucidum extracts for sleep have used dosages ranging from 1,800 mg to 5,400 mg per day, often demonstrating improvements in sleep quality and fatigue reduction. However, these studies primarily used polysaccharide extracts, whereas MG-LZ8 offers a broader range of bioactive compounds, potentially enhancing its effects.

Conclusion and Future Research

While current research supports the role of MG-LZ8 in cortisol modulation, targeted studies are needed to confirm its direct effects on melatonin production and sleep quality. Given its unique bioactive profile and high potency, MG-LZ8 presents a promising natural alternative for individuals experiencing stress-related sleep disturbances.

How to take MG-LZ8 for Sleep Support 

A soothing nighttime latte is one of many easy and practical ways to pair MG-LZ8 into your evening wind-down. Making it an ideal complement for individuals seeking better sleep - whether recovering from a workout, managing stress, or resetting after a long day, have 1 capsule in the evening 1 - 3 hours before bed. 😴

Always follow label directions or consult your healthcare provider for personalized advice.

References:

This study investigated the impact of melatonin supplementation on cortisol levels and sleep quality in hemodialysis patients. Results indicated that melatonin administration significantly reduced nighttime salivary cortisol levels and improved sleep quality. However, the study focused on the effects of melatonin on cortisol, rather than the reverse.

  • Melatonin Improves Mood Status and Quality of Life and Decreases Cortisol Levels in Fibromyalgia.

In this research, fibromyalgia patients received varying doses of melatonin. The findings revealed that melatonin not only improved mood and quality of life but also led to decreased urinary cortisol levels. Again, this study examined the effects of melatonin on cortisol.

  • Temporal Relationship Between Melatonin and Cortisol Responses to Nighttime Physical Stress in Humans.

This study explored how nighttime physical stress affects melatonin and cortisol levels. It was observed that physical stress led to an increase in cortisol levels, which preceded a decrease in melatonin concentration, suggesting a temporal relationship where elevated cortisol may suppress melatonin production.

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